AB0382 DOES THE ULTRASOUND IMAGE OF THE LARGE VESSEL WALLS DIFFER IN THE SUBTYPES OF GCA AND PMR OR THERE IS A SYSTEMIC SUBCLINICAL COMMON INFLAMMATION?

Background: Several clinical patterns of giant cell arteritis (GCA) have been described including cranial GCA (c-GCA), large vessel (LV-GCA), mixed forms c-GCA and LV-GCA (mixed-GCA), even polymyalgia rheumatica (PMR) that has associated with some degree subclinical vascular inflammation could be present in the patients. However, many questions about this disease its subtypes remain unanswered. Objectives: To investigate affectation arterial wall PMR to know if there really are different ultrasound can determined or otherwise they a common systemic only degrees involvement wall. Methods: All available examinations patients referred our fast-track clinic for suspected last three years were reviewed retrospectively collected data. Patients who had undergone examination both vessels (axillary, subclavian carotid arteries) included. The videos images each patient intima-media thickness (IMT) hypoechoic halo measurements taken. data following groups, established according final diagnosis confirmed by doctor after follow-up between six months years, compared: group (within it 3 other groups included: c-GCA, mixed-GCA), without ACG (non-GCA). Results: We analyzed 300 161 baseline 76 (32 14 30 29 56 non-GCA. mean IMT explored statistical significance shown Table 1. arteries except significantly higher mixed-GCA when compared non-GCA groups. There no differences LV-GCA. also any artery statistically significant bilateral axillary all subtypes, being greater latter. tended non-GCA, reaching left subclavian, distal carotid). Although was tendency than patients, did not reach significance. Ultrasound measures GCA, controls Arteries Non-GCA n=56 n=76 n=32 n=14 Mixed-GCA n=30 n=29 p < 0.05 Right (mean ± SD ) 0.67±0.19 0.95±0.30 0.75±0.20 1.03±0.33 1.11±0.27 0.65±0.13 2*, 3*, 4*, 5*, 6, 7*, 8* Left 0.61±0.12 0.92±0.29 0.77±0.19 0.99±0.25 0.66±0.13 1*, 4, 0.70±0.15 1.00±0.31 0.79±0.16 1.09±0.36 1.10±0.29 0.70±0.20 2*,3*, Subclavian 0.62±0.14 0.95±0.27 0.76±0.16 1.05±0.25 1.06±0.26 0.64±0.18 CCD 0.79±0.22 0.97±0.26 0.99±0.22 0.91±0.29 1.05±0.28 0.81±0.10 6*, 0.81±0.16 0.95±0.20 0.97±0.17 1.03±0.27 0.82±0.20 1, 2, 8 SD: Standard deviation; CCD: artery. 1=c-GCA vs non-GCA; 2=LV-GCA 3=mixed-GCA 4=c-GCA LV-GCA; 5=c-GCA mixed-GCA; 6=PMR c-GCA; 7=PMR 8=PMR *p 0.01. Conclusion: Large does differ healthy those GCA. Our suggest subtype is an intermediate form suptypes but inflammatory burden. Disclosure Interests: Elisa Fernández-Fernández: None declared, Iñigo González-Mazón: Irene Monjo Speakers bureau: Roche, Novartis, UCB, Gedeon Richter, Consultant of: José María Mostaza: Carlos Lahoz: Eugenio de Miguel AbbVie, Pfizer, MSD, BMS, Grunental, Janssen, Sanofi, Paid instructor for: Galapagos, Grant/research support from: Abbvie, Pfizer